Knockdown of 5-methylcytosine RNA methyltransferase NOP2/sun RNA methyltransferase 5 in hepatocellular carcinoma cells affects their biological functions

Figure 2 Impact of silencing NOP2/sun RNA methyltransferase 5 on hepatocellular carcinoma cell proliferation and growth. A: NOP2/sun RNA methyltransferase 5 (NSUN5) mRNA expression in HepG2 post-NSUN5 knockdown; B: NSUN5 protein expression in HepG2 post-NSUN5 knockdown; C: HepG2 viability; D: Colony formation ability of HepG2; E: NSUN5 mRNA expression in SMMC-7721; F: NSUN5 protein expression in SMMC-7721; G: SMMC-7721 proliferation capacity; H: Clonogenic potential of SMMC-7721. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. NC: No control; NSUN5: NOP2/sun RNA methyltransferase 5; OD: Optical density.