Knockdown of 5-methylcytosine RNA methyltransferase NOP2/sun RNA methyltransferase 5 in hepatocellular carcinoma cells affects their biological functions

Figure 1 NOP2/sun RNA methyltransferase 5 expression in hepatocellular carcinoma tissues and cell lines. A: NOP2/sun RNA methyltransferase 5 (NSUN5) mRNA expression in hepatocellular carcinoma patients (Gene Expression Profiling Interactive Analysis database, normal tissues are matched The Cancer Genome Atlas adjacent tissue and Genotype-Tissue Expression data); B: Differential NSUN5 mRNA expression levels across different tumor-node-metastasis stages (Gene Expression Profiling Interactive Analysis database); C: NSUN5 mRNA levels across cell lines; D: NSUN5 protein expression across cell lines; E: Intracellular 5-methylcytosine RNA contents; F: The 5-methylcytosine RNA levels in cell culture supernatants. ^aP < 0.05, ^cP < 0.001 vs LO2. LIHC: Liver hepatocellular carcinoma; m5c: 5-methylcytosine; NSUN5: NOP2/sun RNA methyltransferase 5.