Intestinal fibrosis attenuates the prophylactic effect of anti-tumour necrosis factor therapy on the postoperative recurrence of Crohn’s disease

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastrointest Surg. Aug 27, 2025; 17(8): 106455
Published online Aug 27, 2025. doi: 10.4240/wjgs.v17.i8.106455

Table 2 Postoperative recurrence by development of intestinal fibrosis, n (%)

Variables	Total patients	Patients with intestinal fibrosis	Patients without intestinal fibrosis	P value
All recurrence	60 (58.8)	44 (63.8)	16 (48.5)	0.142
Endoscopic recurrence	40 (52.6)	28 (54.9)	12 (48)	0.571
Radiographic recurrence	35 (41.2)	28 (48.3)	7 (25.9)	0.051
Surgical recurrence	11 (10.8)	10 (14.5)	1 (3)	0.099

Citation: Ding ZY, Wang YJ, Yao DH, Tian T, Huang YH, Li YS. Intestinal fibrosis attenuates the prophylactic effect of anti-tumour necrosis factor therapy on the postoperative recurrence of Crohn’s disease. World J Gastrointest Surg 2025; 17(8): 106455
URL: https://www.wjgnet.com/1948-9366/full/v17/i8/106455.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i8.106455

Ding ZY, Wang YJ, Yao DH, Tian T, Huang YH, Li YS. Intestinal fibrosis attenuates the prophylactic effect of anti-tumour necrosis factor therapy on the postoperative recurrence of Crohn’s disease. World J Gastrointest Surg 2025; 17(8): 106455 [PMID: 40949358 DOI: 10.4240/wjgs.v17.i8.106455]

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