MicroRNA 195, lactate dehydrogenase 5, phosphatase and tensin homologue in colorectal cancer: Clinicopathology and prognosis

doi:10.4240/wjgs.v17.i7.107121

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World Journal of Gastrointestinal Surgery

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1948-9366

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World J Gastrointest Surg. Jul 27, 2025; 17(7): 107121
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.107121

Table 2 Correlation of microRNA 195, lactate dehydrogenase-5, and phosphatase and tensin homologue expression with clinicopathological features, n (%)

Clinical features	Factors	n	miR195		χ²	P value	LDH-5		χ²	P value	PTEN		χ²	P value
Clinical features	Factors	n	Positive (n = 19)	Negative (n = 34)	χ²	P value	Positive (n = 42)	Negative (n = 11)	χ²	P value	Positive (n = 15)	Negative (n = 38)	χ²	P value
Sex	Male	30	11 (36.67)	19 (63.33)	0.020	0.887	22 (73.33)	8 (26.67)	1.469	0.225	9 (30.00)	21 (70.00)	0.098	0.754
Sex	Female	23	8 (34.78)	15 (65.22)	0.020	0.887	20 (86.96)	3 (13.04)	1.469	0.225	6 (26.09)	17 (73.91)	0.098	0.754
Age, years	≥ 50	24	9 (37.50)	15 (62.50)	0.052	0.820	18 (75.00)	6 (25.00)	0.481	0.488	9 (37.50)	15 (62.50)	1.829	0.176
Age, years	< 50	29	10 (34.48)	19 (65.52)	0.052	0.820	24 (82.76)	5 (17.24)	0.481	0.488	6 (20.69)	23 (79.31)	1.829	0.176
Tumor site	Colon	28	12 (42.86)	16 (57.14)	1.268	0.260	21 (75.00)	7 (25.00)	0.651	0.420	7 (25.00)	21 (75.00)	0.319	0.572
Tumor site	Rectum	25	7 (28.00)	18 (72.00)	1.268	0.260	21 (84.00)	4 (16.00)	0.651	0.420	8 (32.00)	17 (68.00)	0.319	0.572
TNM stage	I–II	21	13 (61.90)	8 (38.10)	10.268	0.001	13 (61.90)	8 (38.10)	6.359	0.012	8 (38.10)	13 (61.90)	1.644	0.200
TNM stage	III–IV	32	6 (18.75)	26 (81.25)	10.268	0.001	29 (90.63)	3 (9.38)	6.359	0.012	7 (21.88)	25 (78.13)	1.644	0.200
Tumor diameter, cm	≥ 2	23	5 (21.74)	18 (78.26)	3.512	0.061	16 (69.57)	7 (30.43)	2.315	0.128	3 (13.04)	20 (86.96)	4.662	0.031
Tumor diameter, cm	< 2	30	14 (46.67)	16 (53.33)	3.512	0.061	26 (86.67)	4 (13.33)	2.315	0.128	12 (40.00)	18 (60.00)	4.662	0.031
Differentiation degree	Well and moderately	36	16 (44.44)	20 (55.56)	3.601	0.058	25 (69.44)	11 (30.56)	6.555	0.010	12 (33.33)	24 (66.67)	1.400	0.237
Differentiation degree	Poorly	17	3 (17.65)	14 (82.35)	3.601	0.058	17 (100.00)	0 (0)	6.555	0.010	3 (17.65)	14 (82.35)	1.400	0.237
Lymph node metastasis	Presence	29	5 (17.24)	24 (82.76)	9.642	0.002	27 (93.10)	2 (6.90)	7.478	0.006	4 (13.79)	25 (86.21)	6.644	0.010
Lymph node metastasis	Absence	24	14 (58.33)	10 (41.67)	9.642	0.002	15 (62.50)	9 (37.50)	7.478	0.006	11 (45.83)	13 (54.17)	6.644	0.010

miR195: MicroRNA 195; LDH-5: Lactate dehydrogenase-5; PTEN: Phosphatase and tensin homologue; TNM: Tumor, node, metastasis.

Citation: Tang Z, Wen LM. MicroRNA 195, lactate dehydrogenase 5, phosphatase and tensin homologue in colorectal cancer: Clinicopathology and prognosis. World J Gastrointest Surg 2025; 17(7): 107121
URL: https://www.wjgnet.com/1948-9366/full/v17/i7/107121.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i7.107121