Bile spillage in incidental gallbladder cancer is not an independent predictor for survival: A multi-institute retrospective cohort study

Table 3 Analysis of overall survival in patients with incidental gallbladder carcinoma

Characteristic1 (n)	Unadjusted HR (95%CI)	P value2	Adjusted HR (95%CI) (n = 261)	P value3
Age at diagnosis ≥ 65 years (334)4	2.01 (1.46-2.77)	< 0.001	1.80 (1.22-2.66)	0.003
ASA III/IV (319)4	1.81 (1.32-2.47)	< 0.001	1.56 (1.09-2.25)	0.016
Cholecystitis indication for surgery (334)4	1.89 (1.40-2.54)	< 0.001	2.13 (1.50-3.04)	< 0.001
Surgery type laparoscopic (334)5	0.43 (0.32-0.58)	< 0.001
Surgery type converted (334)5	2.44 (1.75-3.41)	< 0.001
Bile spillage (334)4	1.97 (1.48-2.63)	< 0.001	1.21 (0.84-1.74)	0.313
pT stage primary surgery (278)4	1.77 (1.45-2.15)	< 0.001	1.48 (1.17-1.89)	0.001
Positive resection margin at primary surgery (287)4	2.82 (2.05-3.89)	< 0.001	2.42 (1.65-3.55)	< 0.001
pN1 at primary surgery (64)	3.46 (1.59-7.50)	< 0.001

¹Hazard ratios were compared with patients who were negative for the variable for all characteristics except for pT stage.

²P value of log rank testing.

³P value of remaining significant independent variables after multivariable Cox regression analysis.

⁴This characteristic was added to multivariable Cox regression analysis.

⁵Surgery type was not added to multivariable Cox regression analysis as it is directly connected to the other variables used.

HR: Hazard ratio; ASA: American Society of Anesthesiologists Physical Status Classification; CI: Confidence interval.