Acellular mucin in neoplastic and non-neoplastic conditions of the lower gastrointestinal tract

Table 3 Acellular mucin in non-neoplastic lower gastrointestinal tract conditions

Condition	Etiology	Histological findings	Clinical considerations
Appendicitis	Mucin translocation via diverticula or mural defect, common in interval appendectomy	Mucin pools within inflammatory background without epithelial dysplasia	Can mimic LAMN
Colonic diverticulitis	Mural defect, high luminal pressure	Mucin pools following distribution of diverticular pouch	Additional work up to rule out mucinous neoplasia may be required
Crohn’s disease	Mural defect due to prior surgery or fistula	Mucin pools at the site of mural defect	Findings need to be interpreted in an appropriate clinical context
Volvulus	High luminal pressure and microscopic mural defect	Mucin displaced into bowel wall	Findings need to be interpreted in an appropriate clinical context

LAMN: Low-grade appendiceal mucinous neoplasm.