Acellular mucin in neoplastic and non-neoplastic conditions of the lower gastrointestinal tract

doi:10.4240/wjgs.v17.i7.106672

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Jul 27, 2025 (publication date) through Jul 29, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Jul 27, 2025; 17(7): 106672
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.106672

Table 1 Acellular mucin in neoplastic lower gastrointestinal tract conditions

Condition	Key features	Diagnostic implications	Prognosis
Mucinous adenocarcinoma	≥ 50% extracellular mucin, malignant epithelial cells	Confirm site via IHC (CK20, CDX2, SATB2)	Varies by site and molecular alterations
LAMNs/HAMNs	Abundant mucin, no infiltrative growth	Risk of pseudomyxoma peritonei	Generally favorable when organ-confined
SRCC	Signet ring cells	May represent metastasis	Poor prognosis
Serrated adenocarcinoma	Epithelial serration, minimal necrosis, clear or eosinophilic cytoplasm	CIMP (subset)	Unclear

IHC: Immunohistochemistry; CIMP: CpG island methylator phenotype; SRCC: Signet-ring cell carcinoma; LAMNs/HAMNs: Low/high-grade appendiceal mucinous neoplasms.

Citation: Darwish N, Guo L, Park E, Lee H. Acellular mucin in neoplastic and non-neoplastic conditions of the lower gastrointestinal tract. World J Gastrointest Surg 2025; 17(7): 106672
URL: https://www.wjgnet.com/1948-9366/full/v17/i7/106672.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i7.106672