Epidemiology, treatment patterns, and associated risk factors in perianal fistulizing Crohn’s disease: A systematic literature review

Table 3 Summary of overall healing and failure rates per category

	Articles, n	Sample size	Healing/failure1	Follow-up time/time to failure (months)
Healing category
Fistula healing/closure	14	50-253	25.0%-63.2%	12.0-85.2
Partial healing/improvement	3	58-65	10.5%-17.0%	12-45
Radiological healing	3	60-253	18.0%-57.0%	12-48
Failure-free	4	51-157	48.7%-80.2%	12-60
Failure category
Active disease after treatment	4	61-91	15.4%-47.7%	12-31
Additional surgery	4	51-365	13.8%-45.6%	6.8-90.0
Deterioration	1	22	22.0%	45.6
Discontinuation	1	12	12.0%	6
Loss of response	1	236	73.0%	48.0
Recurrence of CPF	15	50-161	3.6%-83.0%	5.5-120.0
Treatment change/escalation	1	51	43.1%	7

¹If cumulative probability of healing at several time points was provided, only the first time point was considered in the range of percent healing.

CPF: Crohn’s perianal fistulas.