Epidemiology, treatment patterns, and associated risk factors in perianal fistulizing Crohn’s disease: A systematic literature review

Table 2 Summary of healing and failure rates for the top five most frequently reported intervention categories

Frequency of healing or failure category, range (number of articles)
	‘Healing’		‘Failure’
Category	Fistula healing/closure	Partial response	Active disease after treatment	Recurrence
Biologics	8.8%-78.4% (n = 17)	11.9%-68.3% (n = 7)	10.7%-55.6% (n = 10)	7.9%-45.0% (n = 5)
Loose seton	17.7%-60.5% (n = 5)	25.0% (n = 1)	41.7%-51.0% (n = 2)	4.0%-68.0% (n = 5)
Surgery (other than seton)	40.7%-75.0% (n = 6)	15.5%-41.6% (n = 3)	22.5%-42.0% (n = 3)	39.5%-64.0% (n = 3)
Immunosuppressants	25.0%-54.8% (n = 3)	19.1% (n = 1)	9.5% (n = 1)	28.6%-46.9% (n = 3)
Fistulectomy/-otomy	47.9%-90.3% (n = 4)	Not reported	3.4% (n = 1)	17.9% (n = 1)

Data presented are for the two most frequently identified healing and failure categories. Details of all the interventions for which healing and failure were assessed can be found in Supplementary Table 4.