Efficacy of reinforcing sutures in preventing anastomotic leakage after surgery for rectal cancer: A systematic review and metaanalysis

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May 27, 2025 (publication date) through May 26, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. May 27, 2025; 17(5): 103758
Published online May 27, 2025. doi: 10.4240/wjgs.v17.i5.103758

Table 4 Results of subgroup analysis of studies - length of the operation

Study characteristics	Number of studies	Number of patients	OR (95%CI)	I², %	P value
Total	20	3726	15.25 (10.71, 19.80)	97	< 0.00001
Study design
RCT	4	547	21.59 (12.37, 30.80)	97	0.13
CCS	16	3179	13.02 (6.76, 19.28)	98
Reinforced anastomosis method
Trans-anal reinforcing	5	410	12.01 (5.20, 18.82)	97	0.25
Laparoscopic reinforcing	15	3316	17.30 (11.25, 23.35)	96
Reinforcing suture
Interrupted suture	6	959	2.58 (-7.02, 12.17)	28	0.006
Continuous suture	13	2473	17.87 (12.88, 22.86)	98
Prophylactic ileostomy
Yes	3	452	1.95 (-8.84, 12.74)	42	0.008
No	17	3274	17.69 (13.23, 22.14)	97

OR: Odds ratio; CI: Confidence interval; RCT: Randomized controlled trial; CCS: Case-control study.

Citation: Zhuang ZX, Zhang Y, Yang XY, Wang ZQ, Deng XB, Zhang MM. Efficacy of reinforcing sutures in preventing anastomotic leakage after surgery for rectal cancer: A systematic review and metaanalysis. World J Gastrointest Surg 2025; 17(5): 103758
URL: https://www.wjgnet.com/1948-9366/full/v17/i5/103758.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i5.103758