Natural surgical risks and age distribution in Chinese patients with Peutz-Jeghers syndrome: Real-world research based on a web survey

Figure 2 The natural cumulative incidence of the first and second surgical procedure in Peutz-Jeghers syndrome. A: The first surgical procedure in Peutz-Jeghers syndrome. The estimated cumulative natural surgical risk for Peutz-Jeghers syndrome was 5.0% (95% confidence interval [CI]: 2.9%-7.0%) at age 5, 20.6% (95%CI: 16.6%-24.4%) at age 10, 40.5% (95%CI: 35.5%-45.1%) at age 15, 58.0% (95%CI: 52.7%-62.7%) at age 20, 72.6% (95%CI: 67.3%-77.0%) at age 25, and 82.4% (95%CI: 77.0%-86.5%) at age 30. The annual growth rate of the cumulative incidence of surgery was 3.38% per year during the age range of 6-25 years, which was higher than the rates observed during the age range of 1-5 years (1.0% per year) or 26-30 years (1.96% per year); B: The second surgical procedure in Peutz-Jeghers syndrome. The estimated cumulative incidence was 3.7% (95%CI: 1.5%-5.8%) for a 1-year interval, 12.5% (95%CI: 8.6%-16.2%) for a 3-year interval, 20.3% (95%CI: 15.6%-24.8%) for a 5-year interval, 37.0% (95%CI: 30.8%-42.7%) for a 10-year interval, and 54.2% (95%CI: 46.8%-60.5%) for a 15-year interval. The annual growth rate of the cumulative incidence of a second surgery was 3.61% per year during the initial 15-year interval since the first surgery.