Optimal timing of endoscopic biliary drainage for bile duct leaks: A multicenter, retrospective, clinical study

Table 3 Univariable and multivariable analysis of factors associated with successful endoscopic retrograde cholangiopancreatography, n (%)

Variable	Univariable analysis			Multivariable analysis
	Success (n = 79)	Failure (n = 15)	P value	OR	95%CI	P value
Basic demographics
Sex, female	24 (30.4)	4 (26.7)	0.773	-	-	-
Age, years, mean ± SD	52.8 ± 12.7	51.0 ± 14.6	0.638	-	-	-
BMI, mean ± SD	23.4 ± 3.4	21.5 ± 3.1	0.049	0.814	0.653-1.014	0.067
CCI, (Q1, Q3)	2.5 (1, 4)	3.0 (2, 7)	0.031	0.864	0.704-1.062	0.164
Laboratory test within 3 days before ERCP
WBC, × 109/L, mean ± SD	9.4 ± 4.3	10.4 ± 5.1	0.390	-	-	-
ALT, U/L (Q1, Q3)	36.1 (25.9, 81.2)	39.6 (22.8, 82.0)	0.812	-	-	-
Tbil, μmol/L (Q1, Q3)	19.3 (12.1, 39.4)	34.0 (12.6, 80.0)	0.715	-	-	-
Albumin, g/L, mean ± SD	35.3 ± 6.0	34.6 ± 5.6	0.659	-	-	-
Creatinine, μmol/L (Q1, Q3)	58.0 (47.0, 69.0)	59.3 (52.0, 99.0)	0.196	-	-	-
Etiology of BDLs	-	-	0.126	-	-	-
Cholecystectomy	58 (73.4)	7 (46.7)	-	-	-	-
Liver transplantation	9 (11.4)	4 (26.7)	-	-	-	-
Partial hepatectomy	7 (8.9)	1 (6.7)	-	-	-	-
Trauma	2 (2.5)	2 (13.3)	-	-	-	-
Others	3 (3.8)	1 (6.7)	-	-	-	-
Characteristics of different methods	--	-	0.326	-	-	-
Plastic stent	50 (63.3)	10 (66.7)	-	-	-	-
Metal stent (10 mm)	2 (2.5)	1 (6.7)	-	-	-	-
Nasobiliary drainage tube	27 (34.2)	4 (26.7)	-	-	-	-
Location of BDLs, cystic duct	51 (64.6)	2 (13.3)	0.002	12.219	2.317-64.433	0.003
Biliary stricture	23 (29.1)	6 (40.0)	0.403	-	-	-
Performing ERCP within 3 weeks	46 (58.2)	4 (26.7)	0.032	4.168	1.031-16.841	0.045
Abdominal drainage	64 (81.0)	12 (15.8)	0.938	-	-	-

OR: Odds ratio; CI: Confidence interval; ERCP: Endoscopic retrograde cholangiopancreatography; BMI: Body mass index; CCI: Charlson comorbidity index; WBC: White blood cell; ALT: Alanine aminotransferase; BDLs: Bile duct leaks; Tbil: Total bilirubin; Q1: First quartile; Q3: Third quartile.