Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review

Table 4 Comparative overview of the outcomes: 90-day mortality

	Pourlotfi et al[9]	Löffler et al[16]
Statin therapy definition	User defined as redeeming 1 or more statin prescriptions 1 year before surgery; postoperative continuation period not stated	Prescribed statins with prescriptions active or in use during the period spanning up to 365 days before surgery
Type of surgical data	Rectal cancer only	Colectomy and rectal resection combined and separate
Surgical procedure	Anterior resection; abdominoperineal resection Hartmann’s operation
Comorbidities	Diabetes; COPD; liver disease, hypertension; congestive heart failure
Results	Unadjusted (statin n/N) 20/3019, PS matched (statin n/N) 20/3017; unadjusted (non-statin n/N) 291/8947, PS matched (non-statin n/N) 166/3017	Statin (n/N) 217/3654; non-statin (n/N) 242/3654

COPD: Chronic obstructive pulmonary disease; n/N: Number of events/total number of individuals in the group; PS: Propensity score.