Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review

Table 3 Comparative overview of the outcomes: 30-day mortality

	Pourlotfi et al[9]	Disbrow et al[10]	Fransgaard et al[11]
Statin therapy definition	User defined as redeeming 1 or more statin prescriptions 1 year before surgery; postoperative continuation period not stated	Ongoing statin therapy No information reported of statin duration of use	Statin user defined as redeeming 2 or more statin prescriptions 1 year before surgery; postoperative continuation period not stated
Type of surgical data	Rectal cancer only	Colectomy and rectal resection combined and separate	Combined colorectal
Surgical procedure	Anterior resection; abdominoperineal resection Hartmann’s operation
Comorbidities	Diabetes; COPD; liver disease, hypertension; congestive heart failure	Diabetes; COPD; ascites/cirrhosis; hypertension; congestive heart failure
Results	Unadjusted (statin n/N) 8/3019, PS matched (statin n/N) 8/3017; unadjusted (non-statin n/N) 8/3017, PS matched (non-statin n/N) 112/3017	Unadjusted (statin n/N) 27/2515, PS matched (statin n/N) 12/1786; unadjusted (non-statin n/N) 35/4770; PS matched (non-statin n/N) 24/1786	Statin (n/N) 316/5961; non-statin (n/N) 1347/23391

COPD: Chronic obstructive pulmonary disease; n/N: Number of events/total number of individuals in the group; PS: Propensity score.