Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review

Table 2 Comparative overview of the outcome: Anastomotic leakage

	Disbrow et al[10]	Fransgaard et al[11]	Bahl et al[15]
Statin therapy definition	No information available concerning statin medication choice, dose, and duration of use	Statin user is defined as redeeming 2 or more statin prescriptions 1 year before surgery; postoperative continuation period not stated	Short-term statin therapy group: Preoperative statin use (3-7 days) and postoperative duration (14 days); long-term statin therapy group: Ongoing statin therapy
Type of surgical data	Colectomy and rectal resection combined and separate	Combined colorectal	Combined colorectal
Comorbidities	Diabetes; COPD; ascites/cirrhosis; hypertension; congestive heart failure	NR	NR
Results	Unadjusted (statin n/N) 41/1810, PS matched (statin n/N) 35/1786; Unadjusted (non-statin n/N) 56/3196, PS Matched (non-statin n/N) 48/1786	OR = 1.03, 95%CI: 0.90-1.18, P = 0.80	Statin (n/N) 8/137; Non-statin (n/N) 3/67

COPD: Chronic obstructive pulmonary disease; n/N: Number of events/total number of individuals in the group; PS: Propensity score; NR: Not reported; OR: Odds ratio; CI: Confidence interval.