Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis

Table 3 Summary of the basic characteristics of the included studies

Ref.	Years	Types	Sample size (n)		Ages (year)		Gender (male/female)		Dose of Ala-Gln	Route	Time of duration
			Control	Experimental	Control	Experimental	Control	Experimental
Zhao et al[30]	2022	CC	44	44	54.31 ± 5.62	55.26 ± 5.86	25/19	23/21	20 g/d	PN	Preop. 3 days-postop
Zhao et al[31]	2019	CRC	28	32	54.42 ± 5.21	56.75 ± 5.60	19/9	22/10	50 mL	PN	Preop. 24 hours and postop. 1 hour
Zhang et al[32]	2008	CRC	47	47	57.35 ± 16.4		NR		100 mL/d	PN	POD1-7
Yuan et al[33]	2011	CRC	30	30	61.83 ± 6.23	62.57 ± 7.38	15/15	15/15	0.4 g /kg/d	PN	Preop. 4 days-postop
Xu et al[34]	2006	CRC	30	30	NR		NR		NR	PN	POD1-7
Wang et al[35]	2005	CRC	20	19	NR		NR		0.4 g /kg/d	PN	Postop.
Wang et al[36]	2008	RC	30	30	60.3 ± 4.5	58.7 ± 3.6	11/19	17/13	0.3 g /kg/d	PN	POD1-7
Song et al[37]	2002	CRC	20	20	56.6 ± 12.1	55.4 ± 17.1	12/8	13/7	0.3-0.4 g /kg/d	PN	POD1-7
Li et al[38]	2002	CRC	20	20	58.02 ± 4.63	57.81 ± 3.75	10/10	11/9	NR	PN	POD1-7
Huang et al[39]	2006	CRC	15	15	56.8 ± 3.5	57.0 ± 4.7	9/6	7/8	0.4 g /kg/d	PN	POD1-5
Cui et al[40]	2011	CC	20	20	56 ± 11	55 ± 11	11/9	12/8	0.5 g/kg	PN	Preop. 24 hours and postop.1 hour
Chen et al[41]	2019	CC	42	42	62.7 ± 11.3	62.1 ± 10.6	24/18	22/20	0.5 g/(kg/d)	PN	Preop-POD 7
Chen et al[42]	2004	CC	24	24	68.12 ± 4.46	66.84 ± 5.52	17/7	15/9	0.4 g /kg/d	PN	Preop. 5 days-POD 7
Cao et al[43]	2007	CRC	20	20	NR		NR		NR	PN	POD1-7
Cao et al[44]	2006	CRC	15	15	NR		NR		NR	PN	Preop. 5 days-POD 5
Oguz et al[45]	2007	CRC	52	57	57 ± 17	52 ± 12	31/21	40/17	1 g /(kg/d)	PN	Preop.: 6 ± 2, POD: 5 ± 1
Morlion et al[46]	1998	CRC	13	15	68.2 ± 12.5	67.1 ± 10.7	6/7	6/9	0.3 g /(kg/d)	PN	POD1-5
Aosasa et al[47]	1999	CRC	5	6	54.8 ± 10.7	63.8 ± 6.2	4/1	3/3	30 g /d	PN	Preop.: > 5 days
Zhang et al[48]	2012	CRC	20	20	42-74		NR		30 g/d	EN	POD1-7
Liu et al[49]	2018	CC	40	40	59.1 ± 7.5	61.4 ± 7.0	25/15	21/19	20 g/d	EN	POD1-7
Liu et al[50]	2017	CC	44	44	59.1 ± 8.5	60.4 ± 7.3	28/16	26/18	20 g /d	EN	POD1-7
Li et al[51]	2016	RC	30	30	50.5 ± 4.9	50.1 ± 4.6	18/12	18/12	0.4 g /kg/d	EN	Postop.
Li et al[52]	2019	CRC	32	32	65.5 ± 9.0	62.6 ± 9 .6	19/13	19/13	0.5 g/ (kg/d)	EN	POD0.5-7
De et al[53]	2020	CC	52	52	53.24 ± 11.38	53.54 ± 11.57	29/23	27/25	100 mL/d	EN	Preop. 1 day- POD 7
Chen et al[54]	2022	CRC	45	45	67.9 ± 7.2	68.5 ± 7.8	25/20	27/18	30 g /d	EN	POD 1-7
Chen et al[55]	2014	CRC	22	22	58.7 ± 6.7		NR		30 g/d	EN	POD1-10
Cai et al[56]	2021	RC	56	56	68.3 ± 3.6	67.2 ± 3.5	34/22	31/25	POD2-3: 5 g, POD4-7: 10 g	EN	POD2-7

PA: Prealbumin; CRC: Colorectal cancer; PN: Parenteral nutrition; EN: Enteral nutrition; POD: Postoperative day; Preop.: Preoperative; Postop.: Postoperative.