Intra-abdominal pressure and procalcitonin for prognosis in patients with severe acute pancreatitis: An etiology-based analysis

Table 4 Efficacy of precision intervention based on propensity score matching

Outcome measures	Intervention group (n = 76)	Conventional group (n = 76)	Relative risk/mean difference (95%CI)	P value
Primary outcomes
28-day all-cause mortality	12 (15.8)	19 (25.0)	0.63 (0.33-0.98)	0.043
180-day mortality	15 (19.7)	23 (30.3)	0.65 (0.37-0.92)	0.038
Secondary outcomes
MODS	37 (48.7)	47 (61.8)	0.79 (0.58-0.96)	0.027
Abdominal compartment syndrome	16 (21.1)	27 (35.5)	0.59 (0.35-0.87)	0.011
ICU admission	44 (57.9)	51 (67.1)	0.86 (0.67-1.03)	0.172
ICU LOS (days), mean ± SD	7.8 ± 4.5	10.3 ± 5.8	-2.5 (-4.1 to -0.9)	0.029
Mechanical ventilation	19 (25.0)	27 (35.5)	0.70 (0.43-1.05)	0.078
Mechanical ventilation duration (days), mean ± SD	4.6 ± 3.1	6.9 ± 4.0	-2.3 (-3.4 to -1.2)	0.003
Infectious complications	24 (31.6)	32 (42.1)	0.75 (0.49-0.98)	0.047
Hospital LOS (days), mean ± SD	18.4 ± 8.6	22.7 ± 10.1	-4.3 (-7.1 to -1.5)	0.036
Total cost (× 10000 RMB), mean ± SD	10.3 ± 5.6	13.8 ± 7.3	-3.5 (-5.6 to -1.4)	0.021
Subgroup analysis
Hypertriglyceridemic AP subgroup (n = 28 pairs)
MODS	11 (39.3)	17 (60.7)	0.65 (0.38-0.94)	0.018
28-day mortality	4 (14.3)	8 (28.6)	0.50 (0.22-0.99)	0.041
Biliary AP subgroup (n = 40 pairs)
MODS	21 (52.5)	28 (70.0)	0.75 (0.52-0.98)	0.032
28-day mortality	7 (17.5)	10 (25.0)	0.70 (0.37-1.33)	0.263
Alcoholic AP subgroup (n = 16 pairs)
MODS	9 (56.3)	11 (68.8)	0.82 (0.47-1.43)	0.465
28-day mortality	3 (18.8)	4 (25.0)	0.75 (0.21-2.65)	0.659
Adjusted analysis
28-day mortality, adjusted OR1	-	-	0.59 (0.29-0.97)	0.038
MODS, adjusted OR1	-	-	0.71 (0.41-0.93)	0.023

¹Adjusted for age, sex, etiology, Acute Physiology and Chronic Health Evaluation II score, baseline intra-abdominal pressure, procalcitonin, and comorbidities.

Data are presented as n (%). Propensity score matching included age, sex, etiology, Acute Physiology and Chronic Health Evaluation II score, body mass index, baseline laboratory values, and admission time. AP: Acute pancreatitis; ICU: Intensive care unit; LOS: Length of stay; MODS: Multiple organ dysfunction syndrome; OR: Odds ratio; CI: Confidence interval; SD: Standard deviation.