Correlation between inflammatory markers and disease severity in ulcerative colitis

Table 2 Univariate analysis of factors associated with disease severity in ulcerative colitis patients, n (%)

Factor	Mild-to-moderate group (n = 82)	Severe group (n = 35)	χ2	P value
Age (years)			0.218	0.640
< 45 (n = 54)	39 (47.56)	15 (42.86)
≥ 45 (n = 63)	43 (52.44)	20 (57.14)
Gender			0.020	0.888
Male (n = 59)	41 (50.00)	18 (51.43)
Female (n = 58)	41 (50.00)	17 (48.57)
BMI (kg/m2)			1.632	0.202
< 23 (n = 54)	41 (50.00)	13 (37.14)
≥ 23 (n = 63)	41 (50.00)	22 (62.86)
Smoking history			4.788	0.029
No (n = 89)	67 (81.71)	22 (62.86)
Yes (n = 28)	15 (18.29)	13 (37.14)
Alcohol abuse history			5.294	0.022
No (n = 83)	64 (78.05)	20 (57.14)
Yes (n = 34)	18 (21.95)	15 (42.86)
Lesion location			0.003	0.954
Rectum (n = 43)	30 (36.59)	13 (37.14)
Colon (n = 74)	52 (63.41)	22 (62.86)
IL-6 (pg/mL)			5.670	0.017
< 13 (n = 46)	38 (46.34)	8 (22.86)
≥ 13 (n = 71)	44 (53.66)	27 (77.14)
TNF-α (pg/mL)			5.606	0.018
< 20 (n = 63)	50 (60.98)	13 (37.14)
≥ 20 (n = 54)	32 (39.02)	22 (62.86)
CRP (mg/L)			5.985	0.014
< 15 (n = 70)	55 (67.07)	15 (42.86)
≥ 15 (n = 47)	27 (32.93)	20 (57.14)

BMI: Body mass index; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; CRP: C-reactive protein.