Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer

doi:10.4240/wjgs.v17.i11.111973

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Nov 27, 2025; 17(11): 111973
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.111973

Table 7 Multivariate logistic regression analysis of each influencing factor and efficacy

Factor	Coefficient	SE	Wald Stat	P value	OR	OR CI lower	OR CI upper
Age (years)	0.049	0.013	3.670	< 0.001	1.050	1.023	1.078
ECOG performance status (0/≥ 1)	-0.498	0.281	-1.774	0.076	0.607	0.350	1.054
TNM stage (≤ II/> II)	-0.427	0.209	-2.047	0.041	0.653	0.434	0.982
Caloric intake (kcal/day)	-0.001	0.001	-1.954	0.051	0.999	0.998	1.000
Protein intake (g/day)	-0.018	0.008	-2.193	0.028	0.982	0.966	0.998
Fiber intake (g/day)	-0.038	0.020	-1.863	0.062	0.963	0.925	1.002
DAO (U/L) postoperative day 7	0.408	0.176	2.317	0.020	1.504	1.065	2.125
I-FABP (μg/L) postoperative day 7	0.017	0.009	1.886	0.059	1.017	0.999	1.036
LPS (U/L) postoperative day 7	0.204	0.073	2.802	0.005	1.226	1.063	1.414
D-Lac (mg/L) postoperative day 7	0.099	0.056	1.768	0.077	1.104	0.989	1.231
Bifidobacterium postoperative day 7	-0.451	0.174	-2.592	0.010	0.637	0.453	0.896
Fusobacterium nucleatum postoperative day 7	0.808	0.287	2.814	0.005	2.244	1.278	3.941
Lactobacillus postoperative day 7	-0.256	0.157	-1.633	0.102	0.774	0.569	1.053
Bacteroides fragilis postoperative day 7	0.842	0.373	2.257	0.024	2.322	1.117	4.824
IgA (g/L) postoperative day 7	-0.330	0.187	-1.765	0.078	0.719	0.498	1.037
IgM (g/L) postoperative day 7	-0.926	0.388	-2.387	0.017	0.396	0.185	0.847
IgG (g/L) postoperative day 7	-0.183	0.058	-3.152	0.002	0.832	0.743	0.933
CD4+/CD8+ postoperative day 7	-0.619	0.301	-2.056	0.040	0.539	0.299	0.971
CRP (mg/L) postoperative day 7	0.094	0.040	2.324	0.020	1.098	1.015	1.188
TNF-α (ng/L) postoperative day 7	0.017	0.010	1.805	0.071	1.018	0.999	1.037
IL-6 (pg/mL) postoperative day 7	0.036	0.017	2.124	0.034	1.037	1.003	1.072

ECOG: Eastern Cooperative Oncology Group performance status; TNM: Tumor node metastasis; DAO: Diamine oxidase; I-FABP: Intestinal fatty acid binding protein; LPS: Lipopolysaccharide; D-Lac: D-lactate; IgM: Immunoglobulin M; IgG: Immunoglobulin G; IgA: Immunoglobulin A; CRP: C-reactive protein; TNF-α: Tumor necrosis factor-alpha; IL-6: Interleukin-6.

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Citation: Zhang Y, Wu J, Yuan Y, Huang YS, Han H. Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer. World J Gastrointest Surg 2025; 17(11): 111973
URL: https://www.wjgnet.com/1948-9366/full/v17/i11/111973.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i11.111973

Zhang Y, Wu J, Yuan Y, Huang YS, Han H. Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer. World J Gastrointest Surg 2025; 17(11): 111973 [PMID: 41357622 DOI: 10.4240/wjgs.v17.i11.111973]

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