Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental studies in rats

Figure 5 Effect of treprostinil and ischemic preconditioning in rats subjected to hepatic ischemia-reperfusion injury. A: Effect of treprostinil and ischemia-reperfusion (IP) on cardiomyocyte necrosis and edema in rats subjected to hepatic ischemia-reperfusion injury (HIRI). The degree of cardiomyocyte necrosis and edema was significantly increased in the HIRI group compared to the sham group. Nonetheless, no statistically significant difference was found between either of the treatment groups and the HIRI group; B: Effect of treprostinil and ischemia-reperfusion on myocardium inflammatory cell infiltrations, presence of wavy fibers and loss of striation in rats subjected to HIRI. The degree of myocardial inflammatory cell infiltrations, presence of wavy fibers and loss of striation was increased in the HIRI group compared to the sham group, but a statistically significant difference was only detected for the loss of striation. There was no statistically significant difference between either treatment group and the HIRI group. Black lines on the top of the bars represent SD. HIRI: Hepatic ischemia-reperfusion injury; IP: Ischemic preconditioning. ^bP < 0.05, and ^cP > 0.05.