Post-endoscopic retrograde cholangiopancreatography pancreatitis: Mechanistic pathways, diagnostic benchmarks, and emerging and mitochondria-targeted therapies

Table 1 Classification of post-endoscopic retrograde cholangiopancreatography pancreatitis

Type	Severity			Advantages and disadvantages
	Mild	Moderate	Severe
Consensus classification[22]	Length of hospital stay as 2-3 days	Length of hospital stay as 4-10 days	A hospital stay of more than 10 days, or the occurrence of hemorrhagic pancreatitis or pancreatic pseudocysts requiring intervention (percutaneous drainage or surgery)	Advantages: (1) Operational simplicity; (2) Strong clinical relevance; and (3) Facilitates statistical analysis and comparison. Disadvantages: (1) Lack of specificity; (2) Lack of sensitivity; and (3) Not applicable to all patient groups
Revised Atlanta classification[27]	The absence of complications	Transient (≤ 48 hours) organ failure or local or systemic complications	Persistent (> 48 hours) organ failure	Advantages: (1) Clear severity grading; (2) Based on clinical symptoms and signs; and (3) Promote clinical research and comparison. Disadvantages: (1) Inadequate identification of mild PEP cases; (2) Lack of reflection on the dynamic changes of the condition; and (3) Incomplete consideration of prognostic factors