Perioperative approach to nephrotoxicity in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

doi:10.4240/wjgs.v17.i10.111885

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastrointest Surg. Oct 27, 2025; 17(10): 111885
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.111885

Table 1 Demographic data and association with acute kidney injury, n (%)

Variable	Total (N = 445)	AKI (n = 61)	No AKI (n = 384)	P value
Age (mean ± SD)	58.6 ± 11.4	62.1 ± 10.2	57.9 ± 11.6	0.021
Gender (female/male)	260/185	38/23	222/162	0.448
BMI (kg/m²)	26.1 ± 3.4	26.8 ± 3.2	26.0 ± 3.4	0.097
≥ 1 comorbidity	302 (67.8)	51 (83.6)	251 (65.3)	0.004
ASA score ≥ III	163 (36.6)	31 (50.8)	132 (34.3)	0.012
Preoperative eGFR < 75 mL/minute/1.73 m²	94 (21.1)	24 (39.3)	70 (18.2)	0.001

SD: Standard deviation, AKI: Acute kidney injury; BMI: Body mass index; ASA: American Society of Anesthesiologists; eGFR: Estimated glomerular filtration rate.

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Citation: Göksu Ş, Düzgün Ö. Perioperative approach to nephrotoxicity in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. World J Gastrointest Surg 2025; 17(10): 111885
URL: https://www.wjgnet.com/1948-9366/full/v17/i10/111885.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i10.111885

Göksu Ş, Düzgün Ö. Perioperative approach to nephrotoxicity in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. World J Gastrointest Surg 2025; 17(10): 111885 [PMID: 41178859 DOI: 10.4240/wjgs.v17.i10.111885]

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