Reduction in the hepatocellular carcinoma antioncogene SLC39A14 during the malignant progression of hepatocellular carcinoma

Figure 13 SLC39A14 is regulated by the transcription factor STAT3. A: Bioinformatics analysis identified STAT3 as one of potential transcription factor driving SLC39A14 expression; B and C: Binding sites for STAT3 in the promoter region of SLC39A14 were identified according to the JASPAR website; D: Pearson’s correlational analysis was performed to explore the correlation between the mRNA levels of STAT3 and SLC39A14 in hepatocellular carcinoma patients in The Cancer Genome Atlas dataset (r = 0.41, P < 0.0001).