Clinical significance of systemic inflammation response index and platelet–lymphocyte ratio in patients with stage I-III gastric cancer

Table 1 Characteristics of training and validation cohorts

Clinicopathologic factors	Training set				P value	Validation set				P value
	Score 0	Score 1	Score 2	Statistic		Score 0	Score 1	Score 2	Statistic
Sex				χ² = 6.85	0.033				χ² = 5.66	0.059
Male	125	245	199			50	113	80
Female	57	65	60			26	29	22
Age (years)				χ² = 1.46	0.481				χ² = 3.80	0.15
≤ 65	112	190	147			51	76	58
> 65	70	120	112			25	66	44
Surgical approach				-	0.176				-	0.03
Open	154	277	234			63	129	88
Laparoscopic	27	32	22			8	11	14
Robotic	1	3	1			5	2	0
Tumor location				χ² = 8.54	0.074				χ² = 0.74	0.946
Cardia and fundus of stomach	98	160	123			36	67	48
Gastric body	27	64	68			13	24	21
Pylorus	57	86	68			27	51	33
Tumor site				χ² = 13.26	0.103				-	0.072
Lesser curvature side	148	246	193			67	114	77
Greater curvature side	20	31	23			5	19	7
Anterior wall	7	15	15			1	3	6
Posterior wall	3	14	16			1	4	8
Total stomach	4	4	12			2	2	4
Pathological type				χ² = 0.10	0.952				χ² = 0.95	0.622
Adenocarcinoma	173	293	246			71	136	95
Others	9	17	13			5	6	7
Differentiation degree				-	0.1751				-	0.196
Poorly differentiated	130	235	177			60	92	68
Moderately differentiated	50	72	81			16	48	33
Highly differentiated	2	3	1			0	2	1
Tumor size				χ² = 68.59	< 0.001				χ² = 2.26	0.323
≤ 5	143	231	119			52	102	64
> 5	39	79	140			24	40	38
T stage				χ² = 28.96	< 0.001				χ² = 13.33	0.038
T1	37	58	21			19	31	13
T2	22	31	15			14	19	8
T3	15	40	27			8	13	8
T4	108	181	196			35	79	73
N stage				χ² = 10.62	0.101				χ² = 13.84	0.031
N0	73	129	83			43	64	38
N1	32	51	42			7	33	17
N2	38	63	52			10	19	15
N3	39	67	82			16	26	32
Neutrophil-to-lymphocyte ratio				χ² = 183.54	< 0.001				χ² = 80.27	< 0.001
≤ 2.98	181	276	132			76	126	51
> 2.98	1	34	127			0	16	51
Systemic immune-inflammation index				χ² = 344.47	< 0.001				χ² = 153.51	< 0.001
≤ 560.54	182	267	68			76	125	26
> 560.54	0	43	191			0	17	76
Carcinoembryonic antigen				χ² = 2.39	0.303				χ² = 2.06	0.358
≤ 4.02	130	211	167			52	106	68
> 4.02	52	99	92			24	36	34

¹Fisher's exact test, simulated P value.