Fibrolamellar hepatocellular carcinoma: Advances, challenges and opportunities in a rare malignancy

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Oct 27, 2025; 17(10): 109107
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.109107

Table 2 Summary of differences between fibrolamellar and convention hepatocellular carcinoma

Feature	FLHCC	Conventional HCC
Typical age group	Adolescents/young adults	Older adults with liver disease
Underlying liver disease	Absent	Often present
AFP elevation	Rare	Common
Histology	Large eosinophilic cells, fibrous lamellae	Variable, often trabecular
Genetic alterations	DNAJB1-PRKACA fusion	TP53, TERT, CTNNB1 mutations
Common metastasis sites	Lymph nodes, lungs, peritoneum	Lungs, bones

AFP: Alpha-fetoprotein; FLHCC: Fibrolamellar hepatocellular carcinoma; HCC: Hepatocellular carcinoma.

Citation: da Fonseca LG, Araujo RLC. Fibrolamellar hepatocellular carcinoma: Advances, challenges and opportunities in a rare malignancy. World J Gastrointest Surg 2025; 17(10): 109107
URL: https://www.wjgnet.com/1948-9366/full/v17/i10/109107.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i10.109107

da Fonseca LG, Araujo RLC. Fibrolamellar hepatocellular carcinoma: Advances, challenges and opportunities in a rare malignancy. World J Gastrointest Surg 2025; 17(10): 109107 [PMID: 41178855 DOI: 10.4240/wjgs.v17.i10.109107]

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