Association between hepatitis B virus markers and liver fibrosis staging in patients with chronic hepatitis B

doi:10.4240/wjgs.v17.i10.106414

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Oct 27, 2025; 17(10): 106414
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.106414

Table 4 Receiver operating characteristic analysis results for hepatitis B core antibody, hepatitis B virus-DNA, and hepatitis B surface antigen in diagnosing liver fibrosis staging

ROC analysis	AUC	95%CI	SE	Sensitivity (%)	Specificity (%)	P value
HBcAb	0.715	0.623-0.807	0.047	69.12	69.23	< 0.001
HBV-DNA	0.799	0.719-0.878	0.041	67.65	76.92	< 0.001
HBsAg	0.662	0.562-0.762	0.051	85.29	44.23	< 0.001
Combined prediction	0.851	0.779-0.923	0.037	85.29	73.08	< 0.001

ROC: Receiver operating characteristic; AUC: Area under the curve; CI: Confidence interval; HBcAb: Hepatitis B core antibody; HBV-DNA: Hepatitis B virus DNA; HBsAg: Hepatitis B surface antigen.

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Citation: Huang XJ, Zheng X, Wang K. Association between hepatitis B virus markers and liver fibrosis staging in patients with chronic hepatitis B. World J Gastrointest Surg 2025; 17(10): 106414
URL: https://www.wjgnet.com/1948-9366/full/v17/i10/106414.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i10.106414

Huang XJ, Zheng X, Wang K. Association between hepatitis B virus markers and liver fibrosis staging in patients with chronic hepatitis B. World J Gastrointest Surg 2025; 17(10): 106414 [PMID: 41178887 DOI: 10.4240/wjgs.v17.i10.106414]

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