Preoperative systemic inflammatory response index as a prognostic marker for distal cholangiocarcinoma after pancreatoduodenectomy

Table 1 The clinical characteristics of primary cohort

Variables	Total (n = 216)	Low SIRI (n = 123)	High SIRI (n = 93)	P value
Patient basic factors
Age (year)
≥ 70	79	35	44	0.004a
< 70	137	88	49
Gender
Male	126	67	59	0.186
Female	90	56	34
Main symptom
Abdominal pain	23	16	7	0.213
Jaundice	182	99	83
Other	11	8	3
Smoking
Yes	64	31	33	0.101
No	152	92	60
Diabetes
Yes	58	31	27	0.530
No	158	92	66
Epigastrium surgery
Yes	20	13	7	0.445
No	196	110	86
Cardiocerebrovascular disease
Yes	109	50	59	0.001a
No	107	73	34
Preoperative biliary drainage
ERCP	24	18	6	< 0.001a
PTBD	81	36	45
No	111	69	42
Laboratory parameters
Platelet (109/L)
≥ 311	43	18	25	0.026a
< 311	173	105	68
WBC (109/L)
≥ 7.2	65	16	49	< 0.001a
< 7.2	151	107	44
Neutrophil (109/L)
≥ 3.6	137	51	86	< 0.001a
< 3.6	79	72	7
Monocyte (109/L)
≥ 0.5	78	17	61	< 0.001a
< 0.5	138	106	32
Lymphocyte (109/L)
≥ 1.8	49	42	7	< 0.001a
< 1.8	167	81	86
ALT (U/L)
≥ 190.5	35	23	12	0.252
< 190.5	181	100	81
AST (U/L)
≥ 16.5	206	118	88	0.650
< 16.5	10	5	5
Hemoglobin (g/L)
≥ 112	132	83	49	0.027a
< 112	84	40	44
Albumin (g/dL)
≥ 35.7	100	66	34	0.013a
< 35.7	116	57	59
TB (μmol/L)
≥ 144.4	83	40	43	0.040a
< 144.4	133	83	50
DB (μmol/L)
≥ 113.8	84	42	42	0.100
< 113.8	132	81	51
-GGT (U/L)
≥ 646.5	66	39	27	0.673
< 646.5	150	84	66
CEA (ng/mL)
≥ 0.2	209	117	92	0.118
< 0.2	7	6	1
CA19-9 (U/mL)
≥ 235.8	61	24	37	0.001a
< 235.8	155	99	56
PLR
≥ 143	145	65	80	< 0.001a
< 143	71	58	13
NLR
≥ 3.1	112	32	80	< 0.001a
< 3.1	104	91	13
LMR
≥ 3.2	100	92	8	< 0.001a
< 3.2	116	31	85
NMR
≥ 11.2	69	37	32	0.499
< 11.2	147	86	61
ABR
≥ 0.3	120	76	44	0.034a
< 0.3	96	47	49
SII
≥ 682	123	39	84	< 0.001a
< 682	93	84	9
ICPI
≥ 445.4	133	57	76	< 0.001a
< 445.4	83	66	17
APRI
≥ 0.3	178	103	75	0.554
< 0.3	38	20	18
Operative outcomes
Operative duration (hours)	10.1 ± 2.6	10.1 ± 2.6	10.1 ± 2.6	0.900
Total blood loss (mL)	618.8 ± 517.5	621.3 ± 535.6	616.8 ± 505.2	0.950
Blood transfusion (mL)	308.3 ± 538.8	259.6 ± 511.0	345.9 ± 558.7	0.244
Postoperative outcomes
Ventilator use duration (hours)	20.9 ± 27.5	18.4 ± 20.9	22.9 ± 31.6	0.234
ICU duration (days)	3.5 ± 3.3	3.4 ± 3.2	3.7 ± 3.6	0.347
Postoperative time (days)	27.0 ± 18.2	26.0 ± 15.8	27.7 ± 19.9	0.498

^aP < 0.05.

PLR: Platelet-to-lymphocyte ratio; NLR: Neutrophil to lymphocyte ratio; LMR: Lymphocyte to monocyte ratio; NMR: Neutrophil-to-monocyte ratio; APRI: Aspartate transaminase-to-platelet; ABR: Albumin to bilirubin ratio; ICPI: Inflammation-combined prognostic index; SII: Systemic immune-inflammation index; SIRI: Systemic inflammatory response index; ERCP: Endoscopic retrograde cholangio pancreatography; PTBD: Percutaneous transhepatic biliary drainage; WBC: White blood count; ALT: Alanine aminotransferase; AST: Aspartate transaminase; TB: Total bilirubin; DB: Direct bilirubin; -GGT: -glutamyl transpeptidase; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; ICU: Intensive care unit.