Analysis of cancer-specific survival in patients with metastatic colorectal cancer: A evidence-based medicine study

Table 2 Multivariate analysis of COX based on training cohorts

Variable	Multivariate analysis
	HR (95%CI)	P value
Race
Black people	1
White race	0.894 (0.834-0.959)	0.002
Other	0.835 (0.752-0.928)	0.001
Sex
Male	1
Female	0.965 (0.918-1.015)	0.17
Age at diagnosis (yr)
< 70	1
≥ 70	1.162 (1.099-1.228)	< 0.001
Primary tumor location
Colon	1
Rectum	0.715 (0.678-0.754)	< 0.001
Tumor differentiation
Ⅰ-Ⅱ	1
Ⅲ-Ⅳ	1.721 (1.630-1.817)	< 0.001
T staging
1-2	1
3-4	1.085 (0.999-1.179)	0.053
N stage
0	1
1-2	1.304 (1.226-1.386)	< 0.001
CEA status
Masculine	1
Feminine	0.699 (0.655-0.746)	< 0.001
Liver metastases
No	1
Yes	1.406 (1.326-1.490)	< 0.001
Lung metastases
No	1
Yes	1.341 (1.260-1.426)	< 0.001
Bone metastases
No	1
Yes	1.621 (1.438-1.827)	< 0.001
Brain metastases
No	1
Yes	1.718 (1.370-2.155)	< 0.001
Surgical
No	1
Yes	0.459 (0.429-0.492)	< 0.001
Chemotherapy
None/unknown	1
Yes	0.368 (0.348-0.390)	< 0.001

CEA: Carcinoembryonic antigen; HR: Hazard ratio.