Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma

Figure 4 Analysis of microRNA targets in tumor vs normal samples and their prognostic significance in cancer. A: Using TargetScan and miRDB databases, 29 intersecting microRNA (miRNA) targets for the PLA2G2A gene; B: Using TargetScan and miRDB databases, 19 intersecting miRNA targets for the PLA2G12B gene; C: Differentially expressed genes between miRNA targets in tumor and normal samples were shown in the volcano plot; D: Forest plot of the univariate Cox regression analysis in co-intersection miRNA targets; E-G: High expression of hsa-miR-363-5p, hsa-miR-4267, and hsa-miR-9-5p genes was associated with a worse prognosis; H: Sankey diagram visual analysis of miRNA targets, PLA2G2A, PLA2G12B, and Hub gene network data.