Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

Table 5 Cox proportional hazards model – all variables; excluded retransplanted patients

Variable	Coefficient (95%CI)	Hazard ratio (95%CI)	P value
Donor pre-procurement cardiac arrest (yes)	0.393 (-0.0281, 0.813)	1.481 (0.972, 2.255)	0.067
Recipient age	0.001 (-0.039, 0.040)	1.001 (0.961, 1.041)	0.98
Donor CRP	0.002 (0.001, 0.004)	1.002 (1.001, 1.004)	0.006
Lab MELD	0.027 (-0.034, 0.088)	1.028 (0.967, 1.092)	0.380
BAR score	0.024 (-0.056, 0.104)	1.024 (0.946, 1.109)	0.557
Indication for LT-cancer (HCC, CCC)	-2.867 (-6.365, 0.631)	0.057 (0.002, 1.878)	0.108
Indication for LT-hepatitis C virus	-4.492 (-9.517, 0.532)	0.011 (0.000, 1.703)	0.080
Indication for LT-miscellaneous	-0.917 (-4.091, 2.257)	0.400 (0.017, 9.555)	0.571
indication for LT-cholestatic disease	0.325 (-3.841, 4.490)	1.384 (0.021, 9.146)	0.879
Lab MELD × cancer (HCC, CCC)	0.026 (-0.030, 0.083)	1.027 (0.970, 1.086)	0.363
Lab MELD × hepatitis C virus	-0.023 (-0.089, 0.044)	0.978 (0.915, 1.044)	0.500
Lab MELD × indication miscellaneous	-0.034 (-0.091, 0.024)	0.967 (0.913, 1.024)	0.253
Lab MELD × cholestatic disease	-0.177 (-0.331, -0.024)	0.838 (0.718, 0.977)	0.023
Recipient age × cancer (HCC, CCC)	0.047 (-0.009, 0.102)	1.048 (0.991, 1.107)	0.098
Recipient age × hepatitis C virus	0.103 (0.021, 0.186)	1.109 (1.022, 1.204)	0.013
Recipient age × indication miscellaneous	0.032 (-0.020, 0.083)	1.033 (0.980, 1.088)	0.228
Recipient age × cholestatic disease	0.038 (-0.036, 0.112)	1.039 (0.965, 1.118)	0.309

The final model did not include any transformations as they were insignificant, and the final model is the (linear) main effects model. Significant interactions between variables are presented. MELD Model for End-Stage liver disease; BAR: Balance of Risk; CRP: C-reactive protein; LT: Liver transplantation; HCC: Hepatocellular carcinoma; CCC: Cholangiocarcinoma.