Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

Table 4 Cox proportional hazards model – excluded metrics (Model for End-Stage Liver Disease, Balance of Risk, and Eurotransplant Donor Risk Index score)

Variable	Coefficient (95%CI)	Hazard ratio (95%CI)	P value
Donor pre-procurement cardiac arrest (yes)	0.401 (0.029, 0.774)	1.494 (1.029, 2.168)	0.035
Recipient age	0.034 (0.016, 0.051)	1.034 (1.016, 1.053)	< 0.001
Donor CRP	0.001 (0.000, 0.003)	1.001 (0.999, 1.003)	0.060
Indication for LT-cancer (HCC, CCC)	0.062 (-0.342, 0.465)	1.064 (0.711, 1.592)	0.764
indication for LT-hepatitis C virus	1.033 (0.515, 1.552)	2.811 (1.673, 4.722)	< 0.001
Indication for LT-re-transplantation	0.806 (0.367, 1.245)	2.240 (1.444, 3.474)	< 0.001
Indication for LT-miscellaneous	0.353 (-0.140, 0.845)	1.423 (0.870, 2.328)	0.160
Indication for LT-cholestatic disease	-0.346 (-1.144, 0.451)	0.707 (0.319, 1.570)	0.395

The final model did not include any transformations and interactions, as they were insignificant, and the final model is the (linear) main effects model. CRP: C-reactive protein; LT: Liver transplantation; HCC: Hepatocellular carcinoma; CCC: Cholangiocarcinoma.