Postoperative serum tumor markers-based nomogram predicting early recurrence for patients undergoing radical resections of pancreatic ductal adenocarcinoma

Table 5 Stratified analysis of clinicopathological variables

Variables	RNS		P value
	High-risk (n = 98)	Low-risk (n = 122)
Operation types (PD/TP)1	90.82	79.51	0.034
Age (> 63)	45.92	38.52	0.333
Gender (male)	62.24	53.28	0.230
Smoking	12.24	18.85	0.251
Drinking	9.18	9.84	1
DM	41.84	33.61	0.265
Jaundice	28.57	27.05	0.921
Tumor_sites2	93.88	86.07	0.096
Tumor_size (> 3.5 cm)	59.18	35.25	< 0.001
Poor_differentiation	62.24	43.44	0.008
Perineural_invasion	95.92	68.85	< 0.001
PV_invasion	52.04	36.89	0.034
Lymphnode_metastasis	58.16	45.90	0.094
pTNM_stage (stage III)	62.24	15.57	< 0.001
Pre_CA19-9 (> 161.50 U/mL)	62.24	31.97	< 0.001
Pre_CEA (> 4.10 ng/mL)	44.90	20.49	< 0.001
Pre_CA125 (> 13.80 U/mL)	77.55	35.25	< 0.001
Af_CA19-9 (> 34.42 U/mL)	62.24	4.92	< 0.001
Af_CEA (> 2.93 ng/mL)	58.16	6.56	< 0.001
Af_CA125 (> 107.00 U/mL)	18.37	15.57	0.711

¹Pancreaticoduodenectomy and total pancreatectomy.

²Head and neck of pancreas.

RNS: Recurrence Nomogram Score; PD: Pancreaticoduodenectomy; TP: Total pancreatectomy; DM: Diabetes mellitus; CA125: Carbohydrate antigen 125; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen.