Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia

Table 2 Univariate and multivariate Cox analyses of overall survival in patients with preoperatively anemic gastric cancer

	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age, yr
< 73
≥ 73	1.886 (1.367-2.602)	< 0.001	2.137 (1.532-2.981)	< 0.001
Sex
Female
Male	1.365 (0.924-2.016)	0.118
Tumor size, cm
< 3.5
≥ 3.5	2.399 (1.561-3.685)	< 0.001
Stage
I
II	2.274 (1.142-4.526)	0.019	1.726 (0.846-3.521)	0.133
III	5.296 (2.827-9.919)	< 0.001	4.231 (2.192-8.167)	< 0.001
IV	14.598 (6.501-32.780)	< 0.001	4.908 (1.426-16.897)	< 0.001
Liver metastasis
No
Yes	5.046 (2.943-8.653)	0.001	3.573 (1.302-9.804)	0.013
Monocyte count, × 109/L
< 0.47
≥ 0.47	2.006 (1.363-2.953)	0.019	1.819 (1.225-2.700)	0.003
Lymphocyte count, × 109/L
< 1.2
≥ 1.2	0.683 (0.498-0.939)	< 0.001	0.645 (0.463-0.898)	0.009
AFP, ng/mL
< 2.6
≥ 2.6	1.983 (1.443-2.725)	< 0.001	1.720 (1.238-2.390)	0.001
Type of surgery
Partial excision
Total Gastrectomy	1.292 (0.940-1.775)	0.114
GC type
Ulcer type
Polyp type	0.97 (0.475-1.979)	0.933	1.527 (0.736-3.167)	0.225
Diffuse type	2.715 (1.256-5.869)	0.011	5.131 (2.266-11.621)	< 0.01
Others	0.17 (0.042-0.687)	0.013	0.353 (0.082-1.517)	0.162
Peritoneal metastasis
No
Yes	3.531 (2.086-5.595)	< 0.001
Lymphatic metastasis
No
Yes	2.879 (1.857-4.465)	< 0.001
Vascular invasion
No
Yes	1.831 (1.332-2.519)	< 0.001
Histological differentiation
Highly or moderately differentiated
Lowly or
undifferentiated	1.848 (1.255-2.271)	0.002
Indolent cell or mucinous adenocarcinoma	1.363 (0.690-2.691)	0.372
Red cell distribution width, %
< 18.9
≥ 18.9	1.88 (1.203-2.938)	0.006
Red blood cell specific volume, L/L
< 0.34
≥ 0.34	1.505 (0.98-2.31)	0.062
Mean corpuscular hemoglobin, pg
< 30.7
≥ 30.7	0.838 (0.674-1.042)	0.112
Mean corpuscular volume, fL
< 87.30
≥ 87.30	1.114 (0.948-1.309)	0.189

HR: Hazard ratio; AFP: Alpha-fetoprotein.