Impact of interstitial cells of Cajal on slow wave and gallbladder contractility in a guinea pig model of acute cholecystitis

Figure 1 Histopathological analysis of a guinea pig model of acute cholecystitis (100 ×). A: Gallbladders in the normal control (NC) group were intact and showed no congestion, edema, or obvious inflammatory cell infiltration. The gallbladders in the acute cholecystitis (AC) groups showed edema, fibroplasia, congestion, mucosal necrosis, considerable inflammatory cell infiltration, and were significantly aggravated over time. In addition, the R-A sinus was present in the lamina propria of the gallbladders in the AC48h group (arrowhead); B: The inflammation score of the NC, AC12h, AC24h, and AC48h groups were 1.20 ± 0.20, 4.00 ± 0.71, 6.80 ± 0.73, and 10.20 ± 0.86, respectively (^aP < 0.05 vs NC groups, ^bP < 0.001 vs NC groups, ^cP < 0.0001 vs NC groups). AC: Acute cholecystitis; NC: Normal control; R-A: Rokitansky-Aschoff; H&E: Hematoxylin and eosin.