Long-term outcomes and failure patterns after laparoscopic intersphincteric resection in ultralow rectal cancers

Table 3 Univariate and multivariate analyses through Cox regression for overall survival

	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age (>60/ ≤ 60 yr)	2.766	1.371–5.582	0.004	2.698	1.329–5.489	0.006
Sex (female/male)	0.713	0.359–1.415	0.333
BMI (> 25/≤ 25 kg/m2)	0.921	0.465–1.862	0.813
CEA (> 5/≤ 5 ng/mL)	1.350	0.690–2.639	0.381
Tumor size (> 40/≤ 40 mm)	1.425	0.742–2.733	0.287
Tumor height from anal verge (cm)	1.499	0.767–2.931	0.236
Lymphovascular invasion (yes/no)	1.768	0.808–3.867	0.154
Nerve invasion (yes/no)	2.596	1.186–5.683	0.017	1.501	0.660–3.414	0.332
(y)p T stage (3/1-2)	3.362	1.541–7.336	0.002	2.293	1.006–5.226	0.048
Lymph node metastasis (yes/no)	2.304	1.218–4.357	0.010	1.713	0.878–3.339	0.114
Differentiation (poor/well-moderate)	3.117	1.472–6.600	0.003	2.234	1.021–4.887	0.044
nCRT (yes/no)	0.525	0.126–2.185	0.376
Adjuvant therapy (yes/no)	1.176	0.622–2.224	0.617

BMI: Body mass index; CEA: Carcinoembryonic antigen; nCRT: Neoadjuvant chemoradiotherapy.