Nutrition in acute pancreatitis

Figure 3 Gut barrier dysfunction and its restoration after enteral nutrition. A: Duodenal biopsy from control shows intact claudin-3 positivity on immunohistochemistry in both villi and crypts throughout the mucosa (× 200); B: Biopsy taken from acute pancreatitis (AP) shows loss of claudin-3 positivity in the duodenal villi and crypts (× 200); C: Biopsy taken from AP post-enteral nutrition shows positivity (significant improvement) in the duodenal villi and crypts (× 200). Ultrastructural changes in duodenal epithelia of patients with AP on electron microscopy show disordered microvilli.