Surveillance strategies following curative resection and non-operative approach of rectal cancer: How and how long? Review of current recommendations

Table 2 Meta-analyses of follow-up studies with different surveillance strategies

Ref.	Studies included and number of patients	Benefit on survival
Bruinvels et al[19], 1993	7 nonrandomized	Yes
	3283 patients
Rosen et al[67], 1998	2 RCTs, 3 nonrandomized	Yes
	2005 patients
Renehan et al[64], 2002	5 RCTs	Yes
	1342 patients
Figueredo et al[68], 2003	6 RCTs	Yes
	1679 patients
Tjandra et al[65], 2007	8 RCTs	Yes
	2923 patients
Pita-Fernández et al[66], 2015	11 RCTs	Yes
	4055 patients
Mokhles et al[69], 2016	11 RCTs	No
	4515 patients
Jeffery et al[70], 2016	15 RCTs	No
	5403 patients

RCT: Randomized controlled trial.