Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma

Table 3 Univariable and multivariable Cox regression analysis of overall survival time in ampullary adenocarcinoma

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Gender
Male		Reference
Female	1.080	0.711-1.639	0.719
Age
< 60		Reference
≥ 60	1.198	0.788-1.822	0.398
Differentiation
Poor		Reference			Reference
Moderate	0.873	0.548-1.391	0.568	0.981	0.600-10603	0.938
Well	0.596	0.344-1.034	0.066	0.979	0.501-1.911	0.949
Tumor size
≤ 2 cm		Reference
> 2 cm	1.139	0.756-1.716	0.534
Perioperative transfusion
No		Reference
Yes	0.861	0.570-1.298	0.474
T stage
I		Reference			Reference
II	0.927	0.485-1.769	0.817	0.792	0.375-1.672	0.541
III	2.128	1.211-3.741	0.009	1.731	0.474-6.322	0.407
Examined lymph nodes
< 12		Reference
≥ 12	1.344	0.881-2.051	0.171
Lymph node metastasis
No		Reference			Reference
Yes	2.203	1.407-3.447	0.001	1.704	0.851-3.412	0.132
TNM stage
I		Reference			Reference
II	1.965	1.230-3.137	0.005	0.886	0.272-2.888	0.841
III	3.030	1.711-5.368	< 0.001	0.918	0.208-4.057	0.910
Vessel invasion
No		Reference
Yes	1.410	0.885-2.248	0.148
Postoperative complications
No		Reference
Yes	1.343	0.886-2.035	0.164
Adjuvant treatment
No		Reference
Yes	0.946	0.590-1.514	0.816
CEA	1.001	0.999-1.004	0.359
CA199	1.000	1.000-1.000	0.585
TBAR	0.966	0.880-1.061	0.470
FAR	0.748	0.359-1.558	0.438
Score
0		Reference			Reference
1	0.787	0.518-1.196	0.262	0.890	0.577-1.373	0.599
2	0.176	0.043-0.726	0.016	0.230	0.054-0.972	0.046

CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199; TNM: Tumor-node-metastasis; FAR: Fibrinogen-albumin ratio; TBAR: Total bilirubin-albumin ratio; HR: Hazard ratio; CI: Confidence interval.