Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma

Table 2 Univariate and multivariate logistic analysis of independent factors predicting the tumor recurrence

Variables	Univariable analysis			Multivariable analysis
	OR	95%CI	P value	OR	95%CI	P value
Gender
Male		Reference
Female	1.176	0.656-2.110	0.586
Age
< 60		Reference
≥ 60	0.747	0.414-1.347	0.332
Differentiation
Poor		Reference
Moderate	1.150	0.596-2.216	0.677
Well	0.599	0.279-1.286	0.189
Tumor size
≤ 2 cm		Reference
> 2 cm	0.879	0.496-1.561	0.661
Perioperative transfusion
No		Reference
Yes	0.619	0.347-1.103	0.104
Operation time
≤ 3 h
> 3 h and ≤ 6 h
> 6 h
T stage
I		Reference			Reference
II	1.197	0.506-2.833	0.683	0.815	0.321-2.064	0.665
III	2.051	0.930-4.521	0.075	0.743	0.132-4.184	0.736
Examined lymph nodes
< 12		Reference
≥ 12	1.359	0.761-2.427	0.300
Lymph node metastasis
No		Reference			Reference
Yes	2.735	1.384-5.406	0.004	1.224	0.425-3.524	0.707
TNM stage
I		Reference			Reference
II	1.560	0.823-2.956	0.173	1.574	0.289-8.574	0.600
III	6.005	2.300-15.676	< 0.001	4.149	0.491-35.043	0.191
Vessel invasion
No		Reference			Reference
Yes	2.601	1.313-5.151	0.006	1.353	0.616-2.970	0.451
Postoperative complications
No		Reference
Yes	0.696	0.387-1.250	0.225
Adjuvant treatment
No		Reference
Yes	1.689	0.893-3.192	0.107
CEA	1.071	0.978-1.172	0.139
CA199	1.000	1.000-1.000	0.824
TBAR	0.988	0.895-1.090	0.807
FAR	0.504	0.182-1.393	0.186
Score
0		Reference			Reference
1	0.469	0.255-0.863	0.015	0.517	0.270-0.988	0.046
2	0.167	0.045-0.630	0.008	0.236	0.060-0.922	0.038

CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199; TNM: Tumor-node-metastasis; FAR: Fibrinogen-albumin ratio; TBAR: Total bilirubin-albumin ratio; OR: Odds ratio; CI: Confidence interval.