Prognostic effect of excessive chemotherapy cycles for stage II and III gastric cancer patients after D2 + gastrectomy

Table 6 Subgroup analysis of progression-free survival by Cox regression analysis of stage III gastric cancer patients

Variables	Death or recurrence	Total	HR	95%CI	P value	P for interaction
Sex						0.418
Male	227	360	0.925	0.712-1.200	0.555
Female	88	124	0.555	0.363-0.846	0.006
Depth of tumor invasion						0.266
T3	65	123	0.719	0.438-1.181	0.193
T4	250	361	0.813	0.649-1.066	0.145
Number of positive lymph nodes						0.170
≤ 6	108	197	0.933	0.640-1.361	0.719
≥ 7	207	287	0.753	0.572-0.990	0.042
Vascular invasion						0.382
Negative	72	119	0.824	0.518-1.311	0.414
Positive	243	365	0.829	0.644-1.068	0.147
Neural invasion						0.469
Negative	92	159	0.961	0.638-1.449	0.851
Positive	223	325	0.773	0.593-1.007	0.056
Lauren classification						0.083
Intestinal	47	88	0.886	0.498-1.576	0.632
Diffuse	193	254	0.923	0.695-1.227	0.042
Mixed	75	142	0.576	0.365-0.910	0.406
Maximum diameter of tumor in cm						0.236
< 6	132	230	0.765	0.543-1.078	0.126
≥ 6	183	254	0.850	0.636-1.136	0.271
Type of gastrectomy						0.605
Proximal	15	25	0.781	0.282-2.162	0.635
Distal	82	142	0.761	0.490-1.181	0.223
Total	218	317	0.830	0.636-1.083	0.169

CI: Confidence interval; HR: Hazard ratio.