Prognostic effect of excessive chemotherapy cycles for stage II and III gastric cancer patients after D2 + gastrectomy

Table 2 Subgroup analysis of overall survival by Cox regression analysis of stage II gastric cancer patients

Variables	Death	Total	HR	95%CI	P value	P for interaction
Sex						0.219
Male	33	156	0.966	0.486-1.919	0.922
Female	6	38	0.520	0.095-2.852	0.452
Depth of tumor invasion						0.749
T1/T2	7	29	0.745	0.164-3.382	0.702
T3/T4	32	165	0.908	0.451-1.828	0.786
Number of positive lymph nodes						0.458
0	21	101	0.584	0.236-1.450	0.247
≥ 1	18	93	1.254	0.492-3.194	0.635
Vascular invasion						0.729
Negative	24	128	1.474	0.535-4.061	0.431
Positive	15	66	0.679	0.246-1.870	0.453
Neural invasion						0.937
Negative	36	163	1.035	0.465-2.306	0.932
Positive	22	93	0.709	0.241-2.083	0.531
Lauren classification						0.553
Intestinal	16	99	0.931	0.568-1.526	0.766
Diffuse	11	40	0.755	0.228-2.506	0.647
Mixed	12	55	1.014	0.570-1.802	0.963
Maximum diameter of tumor in cm						0.167
< 6	20	145	0.986	0.410-2.375	0.976
≥ 6	19	49	0.807	0.317-2.054	0.653
Type of gastrectomy						0.664
Proximal	4	18	1.029	0.378-2.804
Distal	9	58	1.103	0.296-4.111
Total	26	118	0.850	0.575-1.256
HER2						0.656
Negative	21	109	0.858	0.361-2.040
Positive	18	85	0.869	0.343-2.204

CI: Confidence interval; HR: Hazard ratio.