Liver transplantation with simultaneous splenectomy increases risk of cancer development and mortality in hepatocellular carcinoma patients

doi:10.4240/wjgs.v14.i9.930

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Sep 27, 2022 (publication date) through May 10, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Sep 27, 2022; 14(9): 930-939
Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.930

Table 2 Cox proportional hazard model for cancer-free survival

	Univariate		Multivariate
	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Age	1.055 (1.001, 1.112)	0.047^a	1.057 (1.001, 1.117)	0.048^a
Gender/male	1.346 (0.614, 2.950)	0.459	-
BMI	0.937 (0.850, 1.033)	0.191	-
HBV	2.070 (1.005, 4.263)	0.048^a	1.371 (0.632, 2.978)	0.425
HCV	0.687 (0.332-1.423)	0.313	-
Alcoholism	1.751 (0.532-5.769)	0.357	-
Diabetes mellitus	1.062 (0.523, 2.157)	0.868	-
Hypertension	1.704 (0.777, 3.736)	0.183	-
Tumor size	1.057 (0.817, 1.368)	0.672	-
Tumor number (2/3 vs 0/1)	1.577 (0.777, 3.199)	0.207	-
Lymphovascular invasion	1.722 (0.600, 4.945)	0.312	-
Splenectomy	2.754 (1.359, 5.581)	0.005^a	2.560 (1.198, 5.471)	0.015^a
PLT	1.000 (1.000, 1.000)	0.579	-
AFP	1.001 (1.000, 1.002)	0.070	-

^aP < 0.05.

CI: Confidence interval; BMI: Body mass index; HBV: Hepatitis B virus; HCV: Hepatitis C virus; GRWR: Graft-to-recipient weight ratio; INR: International normalized ratio; MELD: The Model for End-stage Liver Disease; AFP: α-fetoprotein.

Citation: Fan HL, Hsieh CB, Kuo SM, Chen TW. Liver transplantation with simultaneous splenectomy increases risk of cancer development and mortality in hepatocellular carcinoma patients. World J Gastrointest Surg 2022; 14(9): 930-939
URL: https://www.wjgnet.com/1948-9366/full/v14/i9/930.htm
DOI: https://dx.doi.org/10.4240/wjgs.v14.i9.930