Early detection of colorectal cancer based on circular DNA and common clinical detection indicators

Table 3 Evaluation of the diagnostic value of 26 commonly used clinical indicators with statistical differences (colon polyp group vs colorectal cancer group)

Indicator	AUC	SE	P value	95% CI
				Lower	Upper
IMA	0.787	0.036	< 0.001	0.716	0.859
CEA	0.734	0.038	< 0.001	0.658	0.809
SA	0.728	0.039	< 0.001	0.651	0.804
LPa	0.715	0.042	< 0.001	0.633	0.797
CK	0.702	0.042	< 0.001	0.619	0.784
TB	0.672	0.044	< 0.001	0.585	0.758
HDL	0.670	0.044	< 0.001	0.583	0.758
NSE	0.668	0.044	< 0.001	0.580	0.755
ALT	0.667	0.044	< 0.001	0.580	0.754
Ferr	0.663	0.045	0.001	0.575	0.751
DB	0.646	0.044	0.002	0.559	0.733
CA125	0.642	0.044	0.003	0.557	0.728
LDH	0.621	0.045	0.011	0.534	0.709
AMY	0.611	0.045	0.019	0.522	0.700
CY211	0.602	0.046	0.032	0.513	0.691
CA724	0.583	0.046	0.081	0.492	0.673
HCY	0.570	0.048	0.138	0.476	0.664
CHO	0.556	0.046	0.240	0.465	0.646
P	0.543	0.047	0.361	0.451	0.636
LDL	0.536	0.046	0.453	0.445	0.626
Cl	0.525	0.047	0.603	0.432	0.618
CKMB	0.516	0.047	0.736	0.424	0.608
CAMK1D	0.652	0.046	0.001	0.561	0.742
PIK3CD	0.753	0.047	< 0.001	0.660	0.845

AUC: Area under the curve; CEA: Carcinoembryonic antigen; AFP: Alpha fetoprotein; CA125: Carbohydrate antigen 125; NSE: Neuron-specific enolase; PG: Pepsinogen; ALT : Alanine aminotransferase; AST: Aspartate aminotransferase; TP: Total protein; ALB: Albumin; TB: Total bilirubin; DB: Direct bilirubin; TBA: Total bile acid; ALP: Alkaline phosphatase; GGT: γ-glutamyl transfer enzyme; CK: Creatine kinase; LDH: Lactate dehydrogenase; CKMB: Creatine kinase isoenzyme; Ca: Calcium; P: Phosphorus; Cl: Chlorine; LPa: Lipoprotein a; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; ApoA1: Apolipoprotein A1; CYS: Cysteine; SA: sialic acid; HCY: Homocysteine; CRP: C-reactive protein; AMY: Amylase; IMA: Ischemia-modified albumin.