Early detection of colorectal cancer based on circular DNA and common clinical detection indicators

Table 2 Comparison of 51 common clinical indicators between colon polyp group and colorectal cancer group

Index	CRP (n = 59)	CRC (n = 101)	F value	Sig	P value
CEA	1.86 (1.17, 2.43)	3.9 (1.67, 13.87)	11.39	< 0.01	< 0.01
AFP	2.58 (1.87, 3.59)	2.41 (1.75, 3.36)	0.02	0.90	0.41
CA125	9.78 (6.77, 13.55)	11.63 (7.98, 19.9)	4.80	0.03	0.04
CA199	8.57 (5.44, 14.38)	13.43 (7.22, 26.48)	3.62	0.06	0.22
CA153	9.5 (7.08, 13.09)	9.25 (6.6, 13)	1.53	0.22	0.49
CA724	1.63 (1.16, 4.39)	2.55 (1.36, 7.33)	5.54	0.02	0.07
CY211	1.82 (1.4, 2.89)	2.3 (1.63, 3.58)	9.29	< 0.01	< 0.01
Ferr	150.9 (85.62, 269.5)	72.12 (17.02, 161.5)	0.11	0.74	0.01
NSE	8.06 (6.52, 9.16)	10 (7.71, 12.63)	4.58	0.03	< 0.01
SCC	1.1 (0.7, 1.5)	0.8 (0.6, 1.2)	2.96	0.09	0.19
PG I/II	4.576 (2.835, 5.914)	5.12 (3.7, 6.53)	0.10	0.76	0.08
PG II	15.9 (9, 28.3)	14.6 (9.7, 24.2)	1.08	0.30	0.64
PG I	75.5 (38.5, 101.3)	71.7 (51.45, 96.3)	0.49	0.49	0.82
ALT	16.8 (12.1, 25)	12.7 (9.3, 17.75)	0.59	0.44	0.03
AST	17.1 (14.1, 20.6)	16.6 (12.25, 19.3)	0.87	0.35	0.43
TP	68.3 (64.1, 71.9)	67.3 (63.15, 70.65)	0.03	0.86	0.29
ALB	41.8 (39.6, 44.4)	39.5 (36.95, 41.45)	0.63	0.43	0.07
TB	12.5 (10, 16.4)	9.7 (7.4, 12.8)	0.75	0.39	< 0.01
DB	4.1 (3.2, 5.2)	3.6 (2.3, 4.2)	0.05	0.82	0.01
TBA	4.2 (2.5, 7.2)	3.5 (2.2, 5.7)	2.15	0.14	0.11
ALP	61.4 (54.8, 73.6)	67 (56.4, 80.05)	2.38	0.13	0.59
GGT	23.6 (13.5, 37.6)	22.3 (14.75, 33.95)	0.01	0.95	0.98
GLu	5.02 (4.79, 5.51)	5.12 (4.74, 5.81)	0.00	0.97	0.97
UN	5.49 (4.64, 6.08)	5.23 (4.08, 6.29)	5.94	0.02	0.43
Cr	70.2 (61.6, 78.6)	65.2 (56.35, 75.6)	0.22	0.64	0.06
UA	312.3 (257.9, 386.9)	292.8 (224, 339.4)	0.19	0.67	0.06
CHO	4.5 (4.04, 5.27)	4.36 (3.88, 5.09)	2.31	0.13	0.02
TG	1.43 (1.01, 2.01)	1.25 (0.93, 1.62)	7.94	0.01	0.45
CK	69.8 (55.5, 118.9)	54.4 (35.2, 71.05)	15.60	< 0.01	0.04
LDH	137 (122.2, 153.3)	148.4 (129.75, 177.75)	4.13	0.04	< 0.01
CKMB	6.6 (4, 9.8)	6.14 (4.05, 9.6)	1.81	0.18	0.02
Ca	2.26 (2.19, 2.31)	2.21 (2.14, 2.27)	0.10	0.75	0.47
P	1.27 (1.14, 1.39)	1.25 (1.07, 1.38)	0.01	0.93	0.01
Mg	0.93 (0.85, 1.01)	0.91 (0.84, 0.97)	0.01	0.94	0.29
K	4.03 (3.78, 4.18)	4.09 (3.87, 4.33)	4.98	0.03	0.53
Na	143.8 (141.6, 145.4)	143.1 (141.45, 144.7)	0.17	0.68	0.12
Cl	105.6 (103.4, 107.2)	105.3 (103.5, 107.4)	2.08	0.15	0.04
CO2	22.6 (20.7, 26.1)	24.9 (22.9, 26.65)	2.31	0.13	0.40
LPa	7.83 (3.01, 12.74)	15.65 (7.82, 31.65)	13.29	< 0.01	0.01
HDL	1.27 (1.03, 1.41)	1.02 (0.89, 1.23)	0.10	0.76	< 0.01
LDL	2.63 (2.26, 3.28)	2.54 (2.07, 3.27)	1.33	0.25	< 0.01
ApoA1	1.39 (1.17, 1.54)	1.13 (1.01, 1.34)	0.66	0.42	0.55
ApoB	0.83 (0.72, 1.02)	0.83 (0.72, 1.01)	0.09	0.76	0.62
CYS	1.07 (0.95, 1.16)	0.97 (0.84, 1.08)	0.34	0.56	0.70
SA	59.3 (55, 66.5)	67.1 (60.8, 82.4)	13.50	< 0.01	0.04
HCY	15.19 (11.54, 19.68)	13.92 (11.18, 17.42)	4.71	0.03	< 0.01
CRP	0.7 (0.4, 1.5)	3.9 (1, 10.55)	30.41	< 0.01	0.11
AMY	59.5 (50, 73.7)	51.8 (38.95, 64.7)	1.18	0.28	< 0.01
LPS	33.1 (25.1, 42.7)	32.9 (22.25, 44.25)	2.87	0.09	0.06
SOD	136.1 (125, 147)	136.5 (115.8, 156.9)	4.82	0.03	0.35
IMA	63.8 (60.1, 66.3)	62.1 (59.45, 67.5)	0.11	0.74	< 0.01
NDUFB7	1.34 (0.94, 2.42)	2.10 (1.29, 3.08)	2.666	0.105	0.155
CAMK1D	34.21 (17.82, 103.44)	70.39 (35.26, 155.57)	3.045	0.083	0.030
PIK3CD	105.90 (36.69, 308.35)	333.22 (259.40, 417.90)	3.700	0.056	0.001
PSEN2	6.46 (4.44, 11.03)	8.69 (6.00, 11.67)	0.144	0.705	0.154

CRP: Colorectal polyps; CRC: Colorectal cancer; CEA: Carcinoembryonic antigen; AFP: Alpha fetoprotein; CA125: Carbohydrate antigen 125; NSE: Neuron-specific enolase; SCC: Squamous cell carcinoma; PG: Pepsinogen; ALT : Alanine aminotransferase; AST: Aspartate aminotransferase; TP: Total protein; ALB: Albumin; TB: Total bilirubin; DB: Direct bilirubin; TBA: Total bile acid; ALP: Alkaline phosphatase; GGT: γ-glutamyl transfer enzyme; Glu: Glucose; UN: Urea nitrogen; Cr: Creatinine; UA: Uric acid; CHO: Cholesterol; TG: Triglyceride esters; CK: Creatine kinase; LDH: Lactate dehydrogenase; CKMB: Creatine kinase isoenzyme; Ca: Calcium; P: Phosphorus; Mg: Magnesium; K: Potassium; Na: Sodium; Cl: Chlorine; CO₂: Carbon dioxide; LPa: Lipoprotein a; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; ApoA1: Apolipoprotein A1; CYS: Cysteine; SA: sialic acid; HCY: Homocysteine; CRP: C-reactive protein; AMY: Amylase; LPS: Lipase; SOD: Superoxide dismutase; IMA: Ischemia-modified albumin.