Short and long-term outcomes between laparoscopic and open total gastrectomy for advanced gastric cancer after neoadjuvant chemotherapy

Table 4 Perioperative clinical indexes and postoperative outcomes between laparoscopic total gastrectomy and open total gastrectomy groups after neoadjuvant chemotherapy (mean ± SD)

Variable	LTG group (n = 61)	OTG group (n = 75)	P value
Surgical time, min	255.66 ± 40.10	238.59 ± 40.30	0.015
Blood loss, mL (median, IQR)	150 (100-300)	200 (200-300)	0.003
Blood loss (mL), n (%)			0.003
< 200	31	13
200-400	20	51
> 400	10	11
Retrieved lymph nodes, n	33.38 ± 13.26	34.75 ± 16.69	0.603
No. 10 lymph nodes dissection			0.339
No	41	56
Yes	20	19
Extent of resection			0.471
R0	58	74
R1/R2	3	1
Time to first flatus, d	4.36 ± 1.28	5.41 ± 1.16	0.000
Postoperative stay, d	9.48 ± 3.98	11.89 ± 3.36	0.000
Surgery costs, $	5419.99 ± 1315.39	4162.36 ± 791.93	0.000
Hospitalization costs, $ (median, IQR)	13105.92 (11713.18-14640.53)	14873.96 (13501.66-17131.31)	0.000
Total complication rate (%)	14 (23.0)	21 (28.0)	0.503
Clavien-Dindo classification
Grade II	12	19
Peritoneal infection	2	2
Lymphatic leakage	2	0
Anastomotic leakage	1	0
Pancreatic fistula	1	1
Ileus	1	2
Cardiac failure	1	0
Hypoproteinemia	2	8
Anemia	2	2
Cholecystitis	0	1
Incision infection	0	2
Pneumonia	0	1
Grade IIIa	1	2
Deep venous thrombosis	1	0
Pleural effusion	0	1
Anastomotic leakage	0	1
Grade V	1	0
Septic shock	1	0
Severe complication rate (%)	2 (3.3)	2 (2.7)	1.000

LTG: Laparoscopic total gastrectomy; OTG: Open total gastrectomy; NACT: Neoadjuvant chemotherapy.