Prognostic factors for patients with mass-forming intrahepatic cholangiocarcinoma: A case series of 68 patients

Table 3 Univariate and multivariate analyses of clinical and pathological factors for overall survival of 68 patients with mass-forming intrahepatic cholangiocarcinoma

Variable	Patients (n)	1 yr (%)	3 yr (%)	5 yr (%)	P value	HR	95%CI	P value
Age (yr)					0.278
≤ 54	35	71.8	39.8	13.5
>54	33	61.4	32.7	6.1
Gender					0.292
Male	50	62.2	34.2	9.7
Female	18	79.6	43.0	10.8
HBV infection					0.327
Yes	16	74.0	24.7	0
No	52	64.0	40.0	13.3
Ascites					< 0.001	5.553	1.628-18.941	0.006
Present	14	0	0	0
Absent	54	84.0	45.8	11.8
Tumor size (cm)					0.230
≤ 7	41	64,3	49.0	10.1
> 7	27	70.2	12.5	6.3
CA 19-9 (IU/mL)					0.881
≤ 27	40	62.7	36.6	7.8
> 27	28	72.3	34.8	15.5
Differentiation					0.009	0.769	0.466-1.270	0.305
Poor	30	56.4	21.7	0
Poor-moderate	24	78.5	62.4	12.8
Moderate	14	66.1	23.6	23.6
Nodal metastasis					< 0.001	2.294	0.983-5.353	0.055
Yes	35	97.0	64.0	21.7
No	33	37.8	9.1	0
Tumor location					0.032	2.186	0.801-5.965	0.127
Left lobe	28	40.9	28.6	0
Right lobe	40	86.8	43.9	12.4
Vascular invasion					< 0.001	2.501	1.020-6.131	0.045
Yes	31	35.5	9.7	0
No	37	97.1	66.3	22.2
Group					< 0.001	1.619	0.351-7.469	0.537
Resection	49	93.5	49.7	14.4
Exploration	19	5.3	5.3	0

HBV: Hepatitis B virus; CA19-9: Carbohydrate antigen 19-9.