Nomograms predicting prognosis of patients with pathological stages T1N2-3 and T3N0 gastric cancer

Table 3 Univariate and multivariate analyses of clinicopathological factors of patients with pT3N0 GC

Characteristic	pT3N0
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex		0.087	-	-
Male	1.000
Female	1.533 (0940-2.500)
Age (yr)	1.029 (1.005-1.054)	0.019	1.025 (1.001-1.049)	0.039
BMI (kg/m2)	0.890 (0.822-0.964)	0.004	0.881 (0.812-0.955)	0.002
Neutrophils (109/L)	0.947 (0.829-1.082)	0.421	-	-
Lymphocytes (109/L)	0.966 (0.719-1.298)	0.819	-	-
Platelets (109/L)	1.000 (0.997-1.003)	0.914	-	-
Fibrinogen (g/L)	1.048 (0.974-1.129)	0.210	-	-
ALT (U/L)	0.992 (0.969-1.015)	0.469	-	-
AST (U/L)	1.012 (0.986-1.037)	0.369	-	-
Albumin (g/L)	0.991 (0.949-1.034)	0.670	-	-
Prealbumin (mg/L)	1.657 (0.954-2.005)	0.087	-	-
CEA (ng/mL)	1.007 (0.985-1.030)	0.535	-	-
CA19-9 (U/mL)	1.002 (0.999-1.004)	0.214	-	-
Tumor diameter (mm)	1.011 (1.004-1.019)	0.003	1.000 (0.990-1.010)	0.981
Borrmann type		0.018		0.282
1	1.000		1.000
2	0.368 (0.159-0.853)	0.020	0.473 (0.195-1.150)	0.099
3	0.520 (0.242-1.119)	0.095	0.620 (0.279-1.377)	0.240
4 or 5	1.110 (0.428-2.879)	0.830	1.051 (0.379-2.911)	0.924
Gastrectomy		< 0.001		< 0.001
Partial gastrectomy	1.000		1.000
Total gastrectomy	3.378 (2.105-5.421)		3.222 (1.945-5.338)
Histological type		0.380	-	-
Differentiated	1.000
Undifferentiated	1.236 (0.771-1.980)
Vascular infiltration		0.237	-	-
No	1.000
Yes	1.142 (0.798-2.499)
Nerve infiltration		0.373	-	-
No	1.000
Yes	1.240 (0772-1.991)
Postoperative chemotherapy		0.238	-	-
Yes	1.000
No	0.774 (0.430-1.393)

CEA and CA19-9 were according to the tumor marker examination. Tumor location, histological type, mLNR, pTstage, pNstage, vascular infiltration, and nerve infiltration were according to the postoperative pathology report. Statistically significant P values are in bold (P < 0.05). HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; ALT: Alanine transaminase; AST: A CEA: Carcino-embryonic antigen; CA19-9: Carbohydrate antigen 19-9; mLNR: Metastatic lymph node ratio.