Nomograms predicting prognosis of patients with pathological stages T1N2-3 and T3N0 gastric cancer

Table 2 Univariate and multivariate analyses of clinicopathological factors of patients with pT1N2-3b GC

Characteristic	pT1N2-3b
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex		0.870	-	-
Male	1.000
Female	0.929 (0.387-2.233)
Age (yr)	1.044 (1.001-1.089)	0.044	1.022 (0.978-1.069)	0.335
BMI (kg/m2)	0.924 (0.815-1.047)	0.216	-	-
Neutrophils (109/L)	1.034 (0.795-1.345)	0.802	-	-
Lymphocytes (109/L)	0.616 (0.297-1.278)	0.193	-	-
Platelets (109/L)	0.999 (0.992-1.006)	0.692	-	-
Fibrinogen (g/L)	1.277 (0.723-2.256)	0.399	-	-
ALT (U/L)	1.000 (0.973-1.029)	0.972	-	-
AST (U/L)	1.016 (0.968-1.067)	0.521	-	-
Albumin (g/L)	0.926 (0.833-1.028)	0.150	-	-
Prealbumin (mg/L)	0.986 (0.977-0.995)	0.003	0.990 (0.981-1.000)	0.040
CEA (ng/mL)	1.254 (1.074-1.464)	0.004	1.199 (1.028-1.399)	0.021
CA19-9 (U/mL)	1.000 (0.972-1.028)	0.992	-	-
Tumor diameter (mm)	0.986 (0.961-1.013)	0.307	-	-
Gastrectomy		0.683	-	-
Partial gastrectomy	1.000
Total gastrectomy	1.356 (0.314-5.851)
Histological type		0.324	-	-
Differentiated	1.000
Undifferentiated	1.665 (0.605-4.581)
pN stage		0.251	-	-
N2	1.000
N3	1.752 (0.673-4.562)
mLNR	47.797 (5.421-421.417)	< 0.001	17.488 (1.215-251.748)	0.035
Vascular infiltration		0.187	-	-
No	1.000
Yes	1.865 (0.738-4.708)
Nerve infiltration		0.989	-	-
No	1.000
Yes	1.010 (0.234-4.359)
Postoperative chemotherapy		0.528	-	-
Yes	1.000
No	0.744 (0.297-1.865)

CEA and CA19-9 were according to the tumor marker examination. Tumor location, histological type, mLNR, pTstage, pNstage, vascular infiltration, and nerve infiltration were according to the postoperative pathology report. Statistically significant P values are in bold (P < 0.05). HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; ALT: Alanine transaminase; AST: A CEA: Carcino-embryonic antigen; CA19-9: Carbohydrate antigen 19-9; mLNR: Metastatic lymph node ratio.