Assessment of tumor markers CA 19-9, CEA, CA 125, and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer

Table 9 Cox proportional hazards model for multivariate regression analysis

Prognostic factor	Parameter estimate	Wald χ2	P value	Hazard ratio	95% CI
CA 19-9	0	0.152	0.697	1	0.999-1.001
CEA	-0.137	1.415	0.234	0.872	0.696-1.093
CA 125	0.001	0.211	0.464	1.001	0.995-1.008
CA 242	0.017	10.422	0.001	1.017	1.007-1.027
LNM	-2.06	6.001	0.014	0.127	0.024-0.662
Age	-0.05	2.814	0.093	0.951	0.897-1.009
Sex	-0.264	0.098	0.755	0.768	0.146-4.027
BMI	0.038	0.478	0.489	1.038	0.933-1.155
GB wall thickness	-0.076	2.096	0.148	0.927	0.837-1.027
Stone size	-0.318	2.114	0.146	0.728	0.474-1.117

95%CI: 95% confidence interval; BMI: Body Mass Index; CA 19-9: Carbohydrate antigen 19-9; CA 125: Carbohydrate antigen 125; CA 242: Carbohydrate antigen 242; CEA: Carcinoembryonic antigen; GB: Gallbladder; LNM: Lymph node metastasis.