Assessment of tumor markers CA 19-9, CEA, CA 125, and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer

Table 6 Performance of markers for predicting gallbladder cancer

Variable	Sensitivity, %	Specificity, %	PPV, %	NPV, %	AUC (95%CI); P value
CA 19-9 (cutoff: 39.21 by ROC)	71.3	90.0	82.6	82.4	0.849 (0.791-0.907); < 0.001
CA 125 (cutoff: 36.00 by ROC)	38.8	93.3	79.5	69.6	0.758 (0.686-0.831); < 0.001
CEA (cutoff: 10.36 by ROC)	12.5	92.5	52.6	61.3	0.623 (0.542-0.703); 0.003
CA 242 (cutoff: 15.10 by ROC)	86.3	90.0	85.2	90.8	0.925 (0.881-0.969); < 0.001

AUC: Area under the curve; CA 19-9: Carbohydrate antigen 19-9; CA 125: Carbohydrate antigen 125; CA 242: Carbohydrate antigen 242; CEA: Carcinoembryonic antigen; NPV: Negative predictive value; PPV: Positive predictive value; ROC: Receiver operating characteristic.